Young couple Madeleine and Neil are coaxed by acquaintance Monsieur Beaumont to get married on his Haitian plantation. Beaumont's motives are purely selfish as he makes every attempt to convince the beautiful young girl to run away with him. For help Beaumont turns to the devious Legendre, a man who runs his mill by mind controlling people he has turned into zombies. After Beaumont uses Legendre's zombie potion on Madeleine, he is dissatisfied with her emotionless being and wants her to be changed back. Legendre has no intention of doing this and he drugs Beaumont as well to add to his zombie collection. Meanwhile, grieving 'widower' Neil is convinced by a local priest that Madeleine may still be alive and he seeks her out.
A mother moves into an old family home to undergo a rigorous treatment that she hopes will help her autistic daughter communicate. The therapy seems successful when the girl miraculously begins to speak. However, she soon discovers that her daughter has come into contact with the tortured entities of the place, who return from beyond to collect a dark debt from the past
年轻女子米歇尔（玛丽·伊丽莎白·温斯特德 Mary Elizabeth Winstead 饰）不久前刚和男友发生争吵，她夜晚驾车奔驰在黑暗的公路上，突然遭遇严重车祸昏迷过去。当她再度醒来时，发现自己被绑住手脚，关在一个密闭的空间里。少顷，一个健硕冷峻的男子霍华德（约翰·古德曼 John Goodman 饰）走了进来。军人出身的霍华德声称地球刚刚遭遇可怕的生化危机，地球人几乎灭亡殆尽。他在数年前未雨绸缪修建了这个设备、资源齐全的避难所，只为生存下去。避难所内，除了霍华德、米歇尔外，还有另外一个年轻男子埃米特。米歇尔对霍华德的说辞半信半疑，她坚信自己遭到了变态狂的拘禁。 真相究竟为何？威胁无处不在……
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